Name Cefuroxime axetil Drug Entry Cefuroxime. Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus. Cefuroxime Axetil (Poorly water soluble drug), when prepared as solid dispersion showed improved solubility and dissolution. Therefore, the main purpose of this investigation was to increase the solubility and dissolution rate of Cefuroxime Axetil by the preparation of its solid dispersion with urea, using the solvent evaporation method. Packaging 100 mg in poly bottle Biochem/physiol Actions Cefuroxime axetil is acetoxyethyl pro-drug cephalosporin with activity against some strains of β-lactamase producing bacteria. System (BCS), cefuroxime axetil is a poorly water soluble drug having class II qualities with low solubility but high permeability (Woo, Chang, 2000). Solubility and permeability are the important parameters in formulation development and regulatory standards. For BCS II, the rate limiting step or the slowest step is drug release from the dosage form and solubility in the gastrointestinal. Cefuroxime Axetil is a second generation semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefuroxime's effect is dependent on its binding to penicillin-binding proteins (PBPs) located in the bacterial cytoplasmic membrane. Cefuroxime Axetil is a second generation semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefuroxime's effect is dependent on its binding to penicillin-binding proteins (PBPs) located in the bacterial cytoplasmic membrane. cefuroxime axetil: product identification. cas no. 64544-07-6: einecs no. formula: c 20 h 22 n 4 o 10 s: mol wt. Improvement in Dissolution Rate of Cefuroxime Axetil by using Poloxamer 188 and Neusilin US2 J. SRUTI*, CH. N. PATRA, S. K. SWAIN. A combination of fusion and surface adsorption techniques was used to enhance the dissolution rate of cefuroxime axetil. Solid dispersions of cefuroxime axetil were prepared by two methods, namely fusion method using poloxamer 188 alone and combination of. poorly water-soluble drug, cefuroxime axetil, and determines the effects the treatment processes have on its solubility. The processes differ in that one renders The solubility of cefuroxime acid in (acetonitrile + water) mixtures was experimentally determined at temperatures from (278.15 to 313.15) K by using a dynamic method at atmospheric pressure.